APOE Genotype Influences Postprandial Blood Pressure after High Fat Feeding in Older Adults.

ABSTRACT:

Objective

Postprandial hypotension (PPH) is a common phenomenon among older adults. The degree to which individuals experience PPH is related to cerebrovascular risk factors and the presence of neurodegenerative diseases such as Alzheimer's disease (AD). Carrier status of the E4 allele of the apolipoprotein E (APOE) gene is a risk factor for AD and influences a variety of responses to metabolic and dietary interventions. However, it is unknown whether APOE genotype influences the risk of PPH and whether type of meal can mediate that response.

Design

Acute meal study with a crossover design.

Participants

32 cognitively healthy older adults with (n=18) and without (n=14) E4+ carrier status.

Intervention

As a part of an ongoing meal study we examined the postprand

SUBMITTER: Stewart KC 

PROVIDER: S-EPMC6544369 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature