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Context-dependent signaling of coincident auditory and visual events in primary visual cortex.

ABSTRACT: Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds.

SUBMITTER: Deneux T

PROVIDER: S-EPMC6544434 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Context-dependent signaling of coincident auditory and visual events in primary visual cortex.

Deneux Thomas T Harrell Evan R ER Kempf Alexandre A Ceballo Sebastian S Filipchuk Anton A Bathellier Brice B

eLife 20190523

Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner ...[more]

PMID: 31115334

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