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Cross-diagnostic analysis of cognitive control in mental illness: Insights from the CNTRACS consortium.


ABSTRACT: BACKGROUND:In recent years, psychiatry research has increasingly focused on understanding mental illnesses from a cross-diagnostic, dimensional perspective in order to better align their neurocognitive features with underlying neurobiological mechanisms. In this multi-site study, we examined two measures of cognitive control (d-prime context and lapsing rate) during the Dot Probe Expectancy (DPX) version of the AX-Continuous Performance Task in patients with either schizophrenia (SZ), schizoaffective disorder (SZ-A), or Type I bipolar disorder (BD) as well as healthy control (HC) subjects. We hypothesized significantly lower d-prime context and higher lapsing rate in SZ and SZ-A patients and intermediate levels in BD patients relative to HC. METHODS:72 HC, 84 SZ, 77 SZ-A, and 58 BD patients (ages 18-56) were included in the final study sample. RESULTS:Significant main effects of diagnosis were observed on d-prime context (F(3,279)?=?9.59, p?

SUBMITTER: Smucny J 

PROVIDER: S-EPMC6544491 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Cross-diagnostic analysis of cognitive control in mental illness: Insights from the CNTRACS consortium.

Smucny Jason J   Barch Deanna M DM   Gold James M JM   Strauss Milton E ME   MacDonald Angus W AW   Boudewyn Megan A MA   Ragland J Daniel JD   Silverstein Steven M SM   Carter Cameron S CS  

Schizophrenia research 20190128


<h4>Background</h4>In recent years, psychiatry research has increasingly focused on understanding mental illnesses from a cross-diagnostic, dimensional perspective in order to better align their neurocognitive features with underlying neurobiological mechanisms. In this multi-site study, we examined two measures of cognitive control (d-prime context and lapsing rate) during the Dot Probe Expectancy (DPX) version of the AX-Continuous Performance Task in patients with either schizophrenia (SZ), sc  ...[more]

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