Cross-diagnostic analysis of cognitive control in mental illness: Insights from the CNTRACS consortium.

ABSTRACT:

Background

In recent years, psychiatry research has increasingly focused on understanding mental illnesses from a cross-diagnostic, dimensional perspective in order to better align their neurocognitive features with underlying neurobiological mechanisms. In this multi-site study, we examined two measures of cognitive control (d-prime context and lapsing rate) during the Dot Probe Expectancy (DPX) version of the AX-Continuous Performance Task in patients with either schizophrenia (SZ), schizoaffective disorder (SZ-A), or Type I bipolar disorder (BD) as well as healthy control (HC) subjects. We hypothesized significantly lower d-prime context and higher lapsing rate in SZ and SZ-A patients and intermediate levels in BD patients relative to HC.

Methods

72 HC, 84 SZ, 77 SZ-A, an

SUBMITTER: Smucny J 

PROVIDER: S-EPMC6544491 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature