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Relationship between neuropsychological behavior and brain white matter in first-episode psychosis.


ABSTRACT: We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus).

SUBMITTER: Faria AV 

PROVIDER: S-EPMC6544495 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Relationship between neuropsychological behavior and brain white matter in first-episode psychosis.

Faria Andreia V AV   Crawford Jeffrey J   Ye Chenfei C   Hsu Johnny J   Kenkare Anshel A   Schretlen David D   Sawa Akira A  

Schizophrenia research 20190413


We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at th  ...[more]

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