Ontology highlight
ABSTRACT:
SUBMITTER: Andica C
PROVIDER: S-EPMC6544650 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Andica Christina C Hagiwara Akifumi A Kamagata Koji K Yokoyama Kazumasa K Shimoji Keigo K Saito Asami A Takenaka Yuki Y Nakazawa Misaki M Hori Masaaki M Cohen-Adad Julien J Takemura Mariko Yoshida MY Hattori Nobutaka N Aoki Shigeki S
Scientific reports 20190531 1
Extensive gray matter (GM) involvement has been demonstrated in multiple sclerosis (MS) patients. This study was aimed to identify GM alterations in relapsing-remitting MS (RRMS) patients using synthetic quantitative MRI (qMRI). We assessed myelin volume fraction (MVF) in each voxel on the basis of R1 and R2 relaxation rates and proton density in 14 early and 28 late (disease duration ≤5 and >5 years, respectively) RRMS patients, and 15 healthy controls (HCs). The MVF and myelin volumes of GM (G ...[more]