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Quantum Shannon theory with superpositions of trajectories.

ABSTRACT: Shannon's theory of information was built on the assumption that the information carriers were classical systems. Its quantum counterpart, quantum Shannon theory, explores the new possibilities arising when the information carriers are quantum systems. Traditionally, quantum Shannon theory has focused on scenarios where the internal state of the information carriers is quantum, while their trajectory is classical. Here we propose a second level of quantization where both the information and its propagation in space-time is treated quantum mechanically. The framework is illustrated with a number of examples, showcasing some of the counterintuitive phenomena taking place when information travels simultaneously through multiple transmission lines.

SUBMITTER: Chiribella G

PROVIDER: S-EPMC6545039 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Quantum Shannon theory with superpositions of trajectories.

Chiribella Giulio G Kristjánsson Hlér H

Proceedings. Mathematical, physical, and engineering sciences 20190508 2225

Shannon's theory of information was built on the assumption that the information carriers were classical systems. Its quantum counterpart, quantum Shannon theory, explores the new possibilities arising when the information carriers are quantum systems. Traditionally, quantum Shannon theory has focused on scenarios where the internal state of the information carriers is quantum, while their trajectory is classical. Here we propose a second level of quantization where both the information and its ...[more]

PMID: 31236050

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Project description:BACKGROUND: The identification of functionally or structurally important non-conserved residue sites in protein MSAs is an important challenge for understanding the structural basis and molecular mechanism of protein functions. Despite the rich literature on compensatory mutations as well as sequence conservation analysis for the detection of those important residues, previous methods often rely on classical information-theoretic measures. However, these measures usually do not take into account dis/similarities of amino acids which are likely to be crucial for those residues. In this study, we present a new method, the Quantum Coupled Mutation Finder (QCMF) that incorporates significant dis/similar amino acid pair signals in the prediction of functionally or structurally important sites. RESULTS: The result of this study is twofold. First, using the essential sites of two human proteins, namely epidermal growth factor receptor (EGFR) and glucokinase (GCK), we tested the QCMF-method. The QCMF includes two metrics based on quantum Jensen-Shannon divergence to measure both sequence conservation and compensatory mutations. We found that the QCMF reaches an improved performance in identifying essential sites from MSAs of both proteins with a significantly higher Matthews correlation coefficient (MCC) value in comparison to previous methods. Second, using a data set of 153 proteins, we made a pairwise comparison between QCMF and three conventional methods. This comparison study strongly suggests that QCMF complements the conventional methods for the identification of correlated mutations in MSAs. CONCLUSIONS: QCMF utilizes the notion of entanglement, which is a major resource of quantum information, to model significant dissimilar and similar amino acid pair signals in the detection of functionally or structurally important sites. Our results suggest that on the one hand QCMF significantly outperforms the previous method, which mainly focuses on dissimilar amino acid signals, to detect essential sites in proteins. On the other hand, it is complementary to the existing methods for the identification of correlated mutations. The method of QCMF is computationally intensive. To ensure a feasible computation time of the QCMF's algorithm, we leveraged Compute Unified Device Architecture (CUDA).The QCMF server is freely accessible at http://qcmf.informatik.uni-goettingen.de/.

Dataset Information

Quantum Shannon theory with superpositions of trajectories.

Publications

Quantum Shannon theory with superpositions of trajectories.

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