Ontology highlight
ABSTRACT:
SUBMITTER: Phelps HM
PROVIDER: S-EPMC6545243 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Phelps Hannah M HM Pierce Janene M JM Murphy Andrew J AJ Correa Hernan H Qian Jun J Massion Pierre P PP Lovvorn Harold N HN
Journal of pediatric surgery 20190228 6
<h4>Background/purpose</h4>Wilms tumor (WT) is the most common childhood kidney cancer globally. Our prior unbiased proteomic screen of WT disparities revealed increased expression of Fragile X-Related 1 (FXR1) in Kenyan specimens where survival is dismal. FXR1 is an RNA-binding protein that associates with poor outcomes in multiple adult cancers. The aim of this study therefore was to validate and characterize the FXR1 expression domain in WT.<h4>Methods</h4>Quantitative FXR1 gene expression wa ...[more]