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Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others' pain.

ABSTRACT: Empathic neural responses to others' suffering are subject to both social and biological influences. The present study tested the hypothesis that empathic neural responses to others' pain are more flexible in an intergroup context in G/G than A/A carriers of the oxytocin receptor gene (OXTR) (rs53576). We recorded event-related brain potentials to painful vs neutral expressions of Asian and Caucasian faces that were assigned to a fellow team or an opponent team in Chinese carriers of G/G or A/A allele of OXTR. We found that G/G carriers showed greater neural responses at 136-176 ms (P2) over the frontal/central region to painful vs neutral expressions of faces with shared either racial or mini group identity. In contrast, A/A carriers showed significant empathic neural responses in the P2 time window only to the faces with both shared racial and mini group identity. Moreover, the racial in-group bias in empathic neural responses varied across individuals' empathy traits and ethnic identity for G/G but not A/A carriers. Our findings provide electrophysiological evidence for greater flexibility of empathic neural responses in intergroup contexts in G/G (vs A/A) carriers of OXTR and suggest interactions between OXTR and intergroup relationships on empathy for others' suffering.

SUBMITTER: Luo S

PROVIDER: S-EPMC6545534 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others' pain.

Luo Siyang S Zhang Ting T Li Wenxin W Yu Meihua M Hein Grit G Han Shihui S

Social cognitive and affective neuroscience 20190501 5

Empathic neural responses to others' suffering are subject to both social and biological influences. The present study tested the hypothesis that empathic neural responses to others' pain are more flexible in an intergroup context in G/G than A/A carriers of the oxytocin receptor gene (OXTR) (rs53576). We recorded event-related brain potentials to painful vs neutral expressions of Asian and Caucasian faces that were assigned to a fellow team or an opponent team in Chinese carriers of G/G or A/A ...[more]

PMID: 31070227

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Project description:BackgroundMajor depressive disorder is strongly associated with impairments and difficulties in social interactions. Deficits in empathy, a vital skill for social interactions, have been identified as a risk factor for relapse. However, research on empathy in remitted states of depression is scarce. We chose a social neuroscience approach to investigate potentially altered neural processes involved in sub-components of empathy in remitted states of depression. We expected aberrations in cognitive components of empathy, based on previous reports regarding their role as risk factors for relapse.MethodsEmploying functional magnetic resonance imaging and a pain empathy task (video clips of painful medical treatments), we compared behavioral and neural empathic responses of unmedicated remitted depressive patients (N = 32) to those of untreated acutely depressed patients (N = 29) and healthy controls (N = 35). Self-report ratings of pain evaluation and affect-sharing were obtained.ResultsCompared to controls and acutely depressed patients, remitted depressive patients reported higher pain evaluation and showed increased activity in the right temporo-parietal junction. This region, which is central to self-other distinction and which has been linked to adopting a detached perspective, also exhibited reduced connectivity to the anterior insula. Furthermore, we observed reduced activity in regions involved in emotion processing (amygdala) and perception of affective facial expressions (fusiform face area, posterior superior temporal sulcus).ConclusionsRemitted states of depression are associated with a detached empathic style in response to others' pain, characterized by increased self-other distinction, lowered affective processing, and reduced connectivity between empathy-related brain regions. Although this may prevent emotional harm in specific situations, it may reduce opportunities for positive experiences in social interactions in the long run.

Dataset Information

Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others' pain.

Publications

Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others' pain.

Similar Datasets

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