Dataset Information

Cost-effectiveness of adult vaccinations: A systematic review.

ABSTRACT:

Background

Coverage levels for many recommended adult vaccinations are low. The cost-effectiveness research literature on adult vaccinations has not been synthesized in recent years, which may contribute to low awareness of the value of adult vaccinations and to their under-utilization. We assessed research literature since 1980 to summarize economic evidence for adult vaccinations included on the adult immunization schedule.

Methods

We searched PubMed, EMBASE, EconLit, and Cochrane Library from 1980 to 2016 and identified economic evaluation or cost-effectiveness analysis for vaccinations targeting persons aged ≥18 years in the U.S. or Canada. After excluding records based on title and abstract reviews, the remaining publications had a full-text review from two independent reviewers, who extracted economic values that compared vaccination to "no vaccination" scenarios.

Results

The systematic searches yielded 1688 publications. After removing duplicates, off-topic publications, and publications without a "no vaccination" comparison, 78 publications were included in the final analysis (influenza = 25, pneumococcal = 18, human papillomavirus = 9, herpes zoster = 7, tetanus-diphtheria-pertussis = 9, hepatitis B = 9, and multiple vaccines = 1). Among outcomes assessing age-based vaccinations, the percent indicating cost-savings was 56% for influenza, 31% for pneumococcal, and 23% for tetanus-diphtheria-pertussis vaccinations. Among age-based vaccination outcomes reporting $/QALY, the percent of outcomes indicating a cost per QALY of ≤$100,000 was 100% for influenza, 100% for pneumococcal, 69% for human papillomavirus, 71% for herpes zoster, and 50% for tetanus-diphtheria-pertussis vaccinations.

Conclusions

The majority of published studies report favorable cost-effectiveness profiles for adult vaccinations, which supports efforts to improve the implementation of adult vaccination recommendations.

SUBMITTER: Leidner AJ

PROVIDER: S-EPMC6545890 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Cost-effectiveness of adult vaccinations: A systematic review.

Leidner Andrew J AJ Murthy Neil N Chesson Harrell W HW Biggerstaff Matthew M Stoecker Charles C Harris Aaron M AM Acosta Anna A Dooling Kathleen K Bridges Carolyn B CB

Vaccine 20181204 2

<h4>Background</h4>Coverage levels for many recommended adult vaccinations are low. The cost-effectiveness research literature on adult vaccinations has not been synthesized in recent years, which may contribute to low awareness of the value of adult vaccinations and to their under-utilization. We assessed research literature since 1980 to summarize economic evidence for adult vaccinations included on the adult immunization schedule.<h4>Methods</h4>We searched PubMed, EMBASE, EconLit, and Cochra ...[more]

PMID: 30527660

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Dataset Information

Cost-effectiveness of adult vaccinations: A systematic review.

Background

Methods

Results

Conclusions

Publications

Cost-effectiveness of adult vaccinations: A systematic review.

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