Ontology highlight
ABSTRACT:
SUBMITTER: Caron P
PROVIDER: S-EPMC6546063 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Caron Pierre P Pankotai Tibor T Wiegant Wouter W WW Tollenaere Maxim A X MAX Furst Audrey A Bonhomme Celine C Helfricht Angela A de Groot Anton A Pastink Albert A Vertegaal Alfred C O ACO Luijsterburg Martijn S MS Soutoglou Evi E van Attikum Haico H
Genes & development 20190502 11-12
DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a pivotal role in transcription inhibition at DSBs by stimulating proteasome-dependent eviction of RNAPII at these lesions. How DNA-PK triggers RNAPII eviction to inhibit transcription at DSBs remains unclear. Here we show that the HECT E3 ubiquitin ligase WWP2 associates with components of the DNA-PK and RNAPII complexes and ...[more]