Association of body mass index and survival in pediatric leukemia: a meta-analysis.

ABSTRACT:

Background

Obesity is a worldwide epidemic in children and adolescents. Adult cohort studies have reported an association between higher body mass index (BMI) and increased leukemia-related mortality; whether a similar effect exists in childhood leukemia remains controversial.

Objective

We conducted a meta-analysis to determine whether a higher BMI at diagnosis of pediatric acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) is associated with worse event-free survival (EFS), overall survival (OS), and cumulative incidence of relapse (CIR).

Design

We searched 4 electronic databases from inception through March 2015 without language restriction and included studies in pediatric ALL or AML (0-21 y of age) reporting BMI as a predictor of survival or relaps

SUBMITTER: Orgel E 

PROVIDER: S-EPMC6546230 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature