Mechanistic analysis of a dynamin effector.
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ABSTRACT:
SUBMITTER: Lackner LL
PROVIDER: S-EPMC6546417 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Mechanistic analysis of a dynamin effector.
Lackner Laura L LL Horner Jennifer S JS Nunnari Jodi J
Science (New York, N.Y.) 20090801 5942
Dynamin-related proteins (DRPs) can generate forces to remodel membranes. In cells, DRPs require additional proteins [DRP-associated proteins (DAPs)] to conduct their functions. To dissect the mechanistic role of a DAP, we used the yeast mitochondrial division machine as a model, which requires the DRP Dnm1, and two other proteins, Mdv1 and Fis1. Mdv1 played a postmitochondrial targeting role in division by specifically interacting and coassembling with the guanosine triphosphate-bound form of D ...[more]
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