Heroin addiction engages negative emotional learning brain circuits in rats.
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ABSTRACT:
SUBMITTER: Carmack SA
PROVIDER: S-EPMC6546476 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Heroin addiction engages negative emotional learning brain circuits in rats.
Carmack Stephanie A SA Keeley Robin J RJ Vendruscolo Janaina C M JCM Lowery-Gionta Emily G EG Lu Hanbing H Koob George F GF Stein Elliot A EA Vendruscolo Leandro F LF
The Journal of clinical investigation 20190326 6
Opioid use disorder (OUD) is associated with the emergence of persistent negative emotional states during drug abstinence that drive compulsive drug taking and seeking. Functional magnetic resonance imaging (fMRI) in rats identified neurocircuits that were activated by stimuli that were previously paired with heroin withdrawal. The activation of amygdala and hypothalamic circuits was related to the degree of heroin dependence, supporting the significance of conditioned negative affect in sustain ...[more]
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