Ontology highlight
ABSTRACT:
SUBMITTER: Mukohda M
PROVIDER: S-EPMC6546477 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Mukohda Masashi M Fang Shi S Wu Jing J Agbor Larry N LN Nair Anand R AR Ibeawuchi Stella-Rita C SC Hu Chunyan C Liu Xuebo X Lu Ko-Ting KT Guo Deng-Fu DF Davis Deborah R DR Keen Henry L HL Quelle Frederick W FW Sigmund Curt D CD
The Journal of clinical investigation 20190321 6
Mice selectively expressing PPARγ dominant negative mutation in vascular smooth muscle exhibit RhoBTB1-deficiency and hypertension. Our rationale was to employ genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle-specific restoration of RhoBTB1 fully corrected the hypertension and arterial stiffness by improving vasodilator function. Notably, the cardiovascular protection occurred despite preservation of increased agonist-mediat ...[more]