Ontology highlight
ABSTRACT:
SUBMITTER: Capitano ML
PROVIDER: S-EPMC6546479 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Capitano Maegan L ML Mor-Vaknin Nirit N Saha Anjan K AK Cooper Scott S Legendre Maureen M Guo Haihong H Contreras-Galindo Rafael R Kappes Ferdinand F Sartor Maureen A MA Lee Christopher T CT Huang Xinxin X Markovitz David M DM Broxmeyer Hal E HE
The Journal of clinical investigation 20190520 6
The nuclear protein DEK is an endogenous DNA-binding chromatin factor regulating hematopoiesis. DEK is one of only 2 known secreted nuclear chromatin factors, but whether and how extracellular DEK regulates hematopoiesis is not known. We demonstrated that extracellular DEK greatly enhanced ex vivo expansion of cytokine-stimulated human and mouse hematopoietic stem cells (HSCs) and regulated HSC and hematopoietic progenitor cell (HPC) numbers in vivo and in vitro as determined both phenotypically ...[more]