ERR1 and PGC1α associated mitochondrial alterations correlate with pan-cancer disparity in African Americans.

ABSTRACT:

Background

African American (AA) patients have higher cancer mortality rates and shorter survival times compared to European American (EA) patients. Despite a significant focus on socioeconomic factors, recent findings strongly argue the existence of biological factors driving this disparity. Most of these factors have been described in a cancer-type specific context rather than a pan-cancer setting.

Methods

A novel in silico approach based on Gene Set Enrichment Analysis (GSEA) coupled to Transcription Factor enrichment was carried out to identify common biological drivers of pan-cancer racial disparity using The Cancer Genome Atlas (TCGA) dataset. Mitochondrial content in patient tissues was examined using a multi-cancer tissue microarray approach (TMA).

Results

Mit

SUBMITTER: Piyarathna DWB 

PROVIDER: S-EPMC6546480 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature