High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.
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ABSTRACT:
SUBMITTER: Nolan SO
PROVIDER: S-EPMC6546518 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.
Nolan Suzanne O SO Hodges Samantha L SL Condon Siena M SM Muhammed Ilyasah D A IDA Tomac Lindsay A LA Binder Matthew S MS Reynolds Conner D CD Lugo Joaquin N JN
Epilepsy & behavior : E&B 20190422
There is increasing evidence that seizures during early development can impact ultrasonic vocalizations (USVs) emitted from neonatal mice. However, most of the effects of early-life seizures have been reported using chemoconvulsants that produce continuous seizures (status epilepticus). In the present study, we evaluated the impact of different seizure frequency loads during early-life vocalization development in C57BL/6J male and female mice. For the high seizure load (HSL) paradigm, we adminis ...[more]
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