Ontology highlight
ABSTRACT:
SUBMITTER: Halpern KB
PROVIDER: S-EPMC6546596 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature biotechnology 20180917 10
Spatially resolved single-cell RNA sequencing (scRNAseq) is a powerful approach for inferring connections between a cell's identity and its position in a tissue. We recently combined scRNAseq with spatially mapped landmark genes to infer the expression zonation of hepatocytes. However, determining zonation of small cells with low mRNA content, or without highly expressed landmark genes, remains challenging. Here we used paired-cell sequencing, in which mRNA from pairs of attached mouse cells wer ...[more]