Bioluminescent-based imaging and quantification of glucose uptake in vivo.
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ABSTRACT:
SUBMITTER: Maric T
PROVIDER: S-EPMC6546603 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Bioluminescent-based imaging and quantification of glucose uptake in vivo.
Maric Tamara T Mikhaylov Georgy G Khodakivskyi Pavlo P Bazhin Arkadiy A Sinisi Riccardo R Bonhoure Nicolas N Yevtodiyenko Aleksey A Jones Anthony A Muhunthan Vishaka V Abdelhady Gihad G Shackelford David D Goun Elena E
Nature methods 20190513 6
Glucose is a major source of energy for most living organisms, and its aberrant uptake is linked to many pathological conditions. However, our understanding of disease-associated glucose flux is limited owing to the lack of robust tools. To date, positron-emission tomography imaging remains the gold standard for measuring glucose uptake, and no optical tools exist for non-invasive longitudinal imaging of this important metabolite in in vivo settings. Here, we report the development of a biolumin ...[more]
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