Ontology highlight
ABSTRACT:
SUBMITTER: Waters LR
PROVIDER: S-EPMC6546716 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Waters Lynnea R LR Ahsan Fasih M FM Ten Hoeve Johanna J Hong Jason S JS Kim Diane N H DNH Minasyan Aspram A Braas Daniel D Graeber Thomas G TG Zangle Thomas A TA Teitell Michael A MA
Scientific reports 20190603 1
Ampk is an energy gatekeeper that responds to decreases in ATP by inhibiting energy-consuming anabolic processes and promoting energy-generating catabolic processes. Recently, we showed that Lkb1, an understudied kinase in B lymphocytes and a major upstream kinase for Ampk, had critical and unexpected roles in activating naïve B cells and in germinal center formation. Therefore, we examined whether Lkb1 activities during B cell activation depend on Ampk and report surprising Ampk activation with ...[more]