Ontology highlight
ABSTRACT:
SUBMITTER: De Mattos-Arruda L
PROVIDER: S-EPMC6546974 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
De Mattos-Arruda Leticia L Sammut Stephen-John SJ Ross Edith M EM Bashford-Rogers Rachael R Greenstein Erez E Markus Havell H Morganella Sandro S Teng Yvonne Y Maruvka Yosef Y Pereira Bernard B Rueda Oscar M OM Chin Suet-Feung SF Contente-Cuomo Tania T Mayor Regina R Arias Alexandra A Ali H Raza HR Cope Wei W Tiezzi Daniel D Dariush Aliakbar A Dias Amarante Tauanne T Reshef Dan D Ciriaco Nikaoly N Martinez-Saez Elena E Peg Vicente V Ramon Y Cajal Santiago S Cortes Javier J Vassiliou George G Getz Gad G Nik-Zainal Serena S Murtaza Muhammed M Friedman Nir N Markowetz Florian F Seoane Joan J Caldas Carlos C
Cell reports 20190501 9
The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones, reveal their predicted neo-antigen landscapes, and show that they can accumulate HLA loss ...[more]