Ontology highlight
ABSTRACT:
SUBMITTER: Gervais L
PROVIDER: S-EPMC6547167 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Gervais Louis L van den Beek Marius M Josserand Manon M Sallé Jérémy J Stefanutti Marine M Perdigoto Carolina N CN Skorski Patricia P Mazouni Khallil K Marshall Owen J OJ Brand Andrea H AH Schweisguth François F Bardin Allison J AJ
Developmental cell 20190501 4
Chromatin remodeling accompanies differentiation, however, its role in self-renewal is less well understood. We report that in Drosophila, the chromatin remodeler Kismet/CHD7/CHD8 limits intestinal stem cell (ISC) number and proliferation without affecting differentiation. Stem-cell-specific whole-genome profiling of Kismet revealed its enrichment at transcriptionally active regions bound by RNA polymerase II and Brahma, its recruitment to the transcription start site of activated genes and deve ...[more]