Ontology highlight
ABSTRACT:
SUBMITTER: Murphy JE
PROVIDER: S-EPMC6547247 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Murphy Janet E JE Wo Jennifer Y JY Ryan David P DP Clark Jeffrey W JW Jiang Wenqing W Yeap Beow Y BY Drapek Lorraine C LC Ly Leilana L Baglini Christian V CV Blaszkowsky Lawrence S LS Ferrone Cristina R CR Parikh Aparna R AR Weekes Colin D CD Nipp Ryan D RD Kwak Eunice L EL Allen Jill N JN Corcoran Ryan B RB Ting David T DT Faris Jason E JE Zhu Andrew X AX Goyal Lipika L Berger David L DL Qadan Motaz M Lillemoe Keith D KD Talele Nilesh N Jain Rakesh K RK DeLaney Thomas F TF Duda Dan G DG Boucher Yves Y Fernández-Del Castillo Carlos C Hong Theodore S TS
JAMA oncology 20190701 7
<h4>Importance</h4>Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant approach is warranted.<h4>Objective</h4>To evaluate the margin-negative (R0) resection rate of neoadjuvant FOLFIRINOX (fluorouracil, leucovorin, oxaliplatin, and irinotecan) and losartan followed by chemoradiotherapy for locally advanced pancreatic cancer.<h4>Design, setting, and participants</h4>A single-arm phase 2 clinical trial was conducted at a large academ ...[more]