Ontology highlight
ABSTRACT:
SUBMITTER: Torres R
PROVIDER: S-EPMC6547438 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Torres Rubén R Carrasco Begoña B Gándara Carolina C Baidya Amit K AK Ben-Yehuda Sigal S Alonso Juan C JC
Nucleic acids research 20190601 10
Bacillus subtilis diadenylate cyclase DisA converts two ATPs into c-di-AMP, but this activity is suppressed upon interaction with sites of DNA damage. DisA forms a rapid moving focus that pauses upon induction of DNA damage during spore development. We report that DisA pausing, however, was not observed in the absence of the RecO mediator or of the RecA recombinase, suggesting that DisA binds to recombination intermediates formed by RecA in concert with RecO. DisA, which physically interacts wit ...[more]