Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance.
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ABSTRACT:
SUBMITTER: Korniy N
PROVIDER: S-EPMC6547452 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance.
Korniy Natalia N Goyal Akanksha A Hoffmann Markus M Samatova Ekaterina E Peske Frank F Pöhlmann Stefan S Rodnina Marina V MV
Nucleic acids research 20190601 10
A hallmark of translation in human immunodeficiency virus type 1 (HIV-1) is a -1 programmed ribosome frameshifting event that produces the Gag-Pol fusion polyprotein. The constant Gag to Gag-Pol ratio is essential for the virion structure and infectivity. Here we show that the frameshifting efficiency is modulated by Leu-tRNALeu that reads the UUA codon at the mRNA slippery site. This tRNALeu isoacceptor is particularly rare in human cell lines derived from T-lymphocytes, the cells that are targ ...[more]
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