Ontology highlight
ABSTRACT:
SUBMITTER: Basile A
PROVIDER: S-EPMC6547619 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Molecular oncology 20190517 6
We have previously shown that secreted BAG3 is a potential target for the treatment of pancreatic ductal adenocarcinoma and that pancreatic tumor growth and metastatic dissemination can be reduced by treatment with an anti-BAG3 murine antibody. Here, we used complementarity-determining region (CDR) grafting to generate a humanized version of the anti-BAG3 antibody that may be further developed for possible clinical use. We show that the humanized anti-BAG3 antibody, named BAG3-H2L4, abrogates BA ...[more]