Heterochronic faecal transplantation boosts gut germinal centres in aged mice.
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ABSTRACT:
SUBMITTER: Stebegg M
PROVIDER: S-EPMC6547660 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Heterochronic faecal transplantation boosts gut germinal centres in aged mice.
Stebegg Marisa M Silva-Cayetano Alyssa A Innocentin Silvia S Jenkins Timothy P TP Cantacessi Cinzia C Gilbert Colin C Linterman Michelle A MA
Nature communications 20190604 1
Ageing is a complex multifactorial process associated with a plethora of disorders, which contribute significantly to morbidity worldwide. One of the organs significantly affected by age is the gut. Age-dependent changes of the gut-associated microbiome have been linked to increased frailty and systemic inflammation. This change in microbial composition with age occurs in parallel with a decline in function of the gut immune system; however, it is not clear whether there is a causal link between ...[more]
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