Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC6547712 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zhou Jie J Huang Shuo S Wang Zhongyu Z Huang Jiani J Xu Liang L Tang Xuefeng X Wan Yisong Y YY Li Qi-Jing QJ Symonds Alistair L J ALJ Long Haixia H Zhu Bo B
Nature communications 20190603 1
Enhancer of zeste homolog 2 (EZH2)-mediated trimethylation of histone 3 lysine 27 (H3K27Me3) is critical for immune regulation. However, evidence is lacking to address the effect of EZH2 enzyme's activity on intestinal immune responses during inflammatory bowel disease (IBD). Here we report that suppressing EZH2 activity ameliorates experimental intestinal inflammation and delayed the onset of colitis-associated cancer. In addition, we identified an increased number of functional MDSCs in the co ...[more]