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Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.


ABSTRACT: How antibodies naturally acquired during Plasmodium falciparum infection provide clinical immunity to blood-stage malaria is unclear. We studied the function of natural killer (NK) cells in people living in a malaria-endemic region of Mali. Multi-parameter flow cytometry revealed a high proportion of adaptive NK cells, which are defined by the loss of transcription factor PLZF and Fc receptor ?-chain. Adaptive NK cells dominated antibody-dependent cellular cytotoxicity responses, and their frequency within total NK cells correlated with lower parasitemia and resistance to malaria. P. falciparum-infected RBCs induced NK cell degranulation after addition of plasma from malaria-resistant individuals. Malaria-susceptible subjects with the largest increase in PLZF-negative NK cells during the transmission season had improved odds of resistance during the subsequent season. Thus, antibody-dependent lysis of P. falciparum-infected RBCs by NK cells may be a mechanism of acquired immunity to malaria. Consideration of antibody-dependent NK cell responses to P. falciparum antigens is therefore warranted in the design of malaria vaccines.

SUBMITTER: Hart GT 

PROVIDER: S-EPMC6547858 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Adaptive NK cells in people exposed to <i>Plasmodium falciparum</i> correlate with protection from malaria.

Hart Geoffrey T GT   Tran Tuan M TM   Theorell Jakob J   Schlums Heinrich H   Arora Gunjan G   Rajagopalan Sumati S   Sangala A D Jules ADJ   Welsh Kerry J KJ   Traore Boubacar B   Pierce Susan K SK   Crompton Peter D PD   Bryceson Yenan T YT   Long Eric O EO  

The Journal of experimental medicine 20190412 6


How antibodies naturally acquired during <i>Plasmodium falciparum</i> infection provide clinical immunity to blood-stage malaria is unclear. We studied the function of natural killer (NK) cells in people living in a malaria-endemic region of Mali. Multi-parameter flow cytometry revealed a high proportion of adaptive NK cells, which are defined by the loss of transcription factor PLZF and Fc receptor γ-chain. Adaptive NK cells dominated antibody-dependent cellular cytotoxicity responses, and thei  ...[more]

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