Ontology highlight
ABSTRACT:
SUBMITTER: Hart GT
PROVIDER: S-EPMC6547858 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Hart Geoffrey T GT Tran Tuan M TM Theorell Jakob J Schlums Heinrich H Arora Gunjan G Rajagopalan Sumati S Sangala A D Jules ADJ Welsh Kerry J KJ Traore Boubacar B Pierce Susan K SK Crompton Peter D PD Bryceson Yenan T YT Long Eric O EO
The Journal of experimental medicine 20190412 6
How antibodies naturally acquired during <i>Plasmodium falciparum</i> infection provide clinical immunity to blood-stage malaria is unclear. We studied the function of natural killer (NK) cells in people living in a malaria-endemic region of Mali. Multi-parameter flow cytometry revealed a high proportion of adaptive NK cells, which are defined by the loss of transcription factor PLZF and Fc receptor γ-chain. Adaptive NK cells dominated antibody-dependent cellular cytotoxicity responses, and thei ...[more]