Ontology highlight
ABSTRACT:
SUBMITTER: Webb LM
PROVIDER: S-EPMC6547860 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Webb Lauren M LM Oyesola Oyebola O OO Früh Simon P SP Kamynina Elena E Still Katherine M KM Patel Ravi K RK Peng Seth A SA Cubitt Rebecca L RL Grimson Andrew A Grenier Jennifer K JK Harris Tajie H TH Danko Charles G CG Tait Wojno Elia D ED
The Journal of experimental medicine 20190411 6
Type 2 inflammation drives the clearance of gastrointestinal helminth parasites, which infect over two billion people worldwide. Basophils are innate immune cells that support host-protective type 2 inflammation during murine infection with the helminth <i>Trichuris muris</i> However, the mechanisms required for basophil function and gene expression regulation in this context remain unclear. We show that during <i>T. muris</i> infection, basophils localized to the intestine and up-regulated Notc ...[more]