Ontology highlight
ABSTRACT:
SUBMITTER: Zhou F
PROVIDER: S-EPMC6548130 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zhou Fan F Wu Zulin Z Zhao Mengzhu M Murtazina Rakhilya R Cai Juan J Zhang Ao A Li Rui R Sun Dan D Li Wenjing W Zhao Lei L Li Qunli Q Zhu Jing J Cong Xiaoxia X Zhou Yiting Y Xie Zhiping Z Gyurkovska Valeriya V Li Liuju L Huang Xiaoshuai X Xue Yanhong Y Chen Liangyi L Xu Hui H Xu Haiqian H Liang Yongheng Y Segev Nava N
The Journal of cell biology 20190422 6
In the conserved autophagy pathway, autophagosomes (APs) engulf cellular components and deliver them to the lysosome for degradation. Before fusing with the lysosome, APs have to close via an unknown mechanism. We have previously shown that the endocytic Rab5-GTPase regulates AP closure. Therefore, we asked whether ESCRT, which catalyzes scission of vesicles into late endosomes, mediates the topologically similar process of AP sealing. Here, we show that depletion of representative subunits from ...[more]