Ontology highlight
ABSTRACT:
SUBMITTER: Ye N
PROVIDER: S-EPMC6548324 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Ye Na N Li Bang B Mao Qi Q Wold Eric A EA Tian Sheng S Allen John A JA Zhou Jia J
ACS chemical neuroscience 20181220 1
Although G protein-coupled receptors (GPCRs) are recognized as pivotal drug targets involved in multiple physiological and pathological processes, the majority of GPCRs including orphan GPCRs (oGPCRs) are unexploited. GPR88, a brain-specific oGPCR with particularly robust expression in the striatum, regulates diverse brain and behavioral functions, including cognition, mood, movement control, and reward-based learning, and is thus emerging as a novel drug target for central nervous system disord ...[more]