JmjC histone demethylases act as chromatin oxygen sensors.
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ABSTRACT:
SUBMITTER: Batie M
PROVIDER: S-EPMC6548480 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
JmjC histone demethylases act as chromatin oxygen sensors.
Molecular & cellular oncology 20190507 4
Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia. ...[more]
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