Autophagy represses hepatic carcinogenesis.
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ABSTRACT:
SUBMITTER: Paillet J
PROVIDER: S-EPMC6548487 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Autophagy represses hepatic carcinogenesis.
Paillet Juliette J Kroemer Guido G
Molecular & cellular oncology 20190513 4
Hepatocyte-specific knockout of the essential autophagy gene Autophagy-related 7 (<i>Atg7)</i> is sufficient to cause hepatic carcinogenesis. A recent paper by Lee et al. unveils the molecular pathway accounting for hepatic hypertrophy and hyperplasia followed by malignant transformation. This pathway involves the overactivation of the transcription factor yes-associated protein (YAP), which turns out to be an autophagic substrate. Of note, the transcriptional signature activated in mouse hepato ...[more]
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