Sp3-cificity of TNF-? expression promotes the Smac mimetic-mediated killing of cancer cells.
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ABSTRACT:
SUBMITTER: Beug ST
PROVIDER: S-EPMC6548490 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells.
Beug Shawn T ST Korneluk Robert G RG LaCasse Eric C EC
Molecular & cellular oncology 20190508 4
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required for the expression of the cytokine Tumor Necrosis Factor alpha (TNF-α) under basal and Smac mimetic-stimulated conditions. ...[more]
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