Prostaglandin E₂ Inhibits the Ability of Neutrophils to Kill Listeria monocytogenes.

ABSTRACT: PGE₂ is a lipid-signaling molecule with complex roles in both homeostasis and inflammation. Depending on the cellular context, PGE₂ may also suppress certain immune responses. In this study, we tested whether PGE₂ could inhibit bacterial killing by polymorphonuclear neutrophils (PMN) using a mouse model of foodborne listeriosis. We found that PGE₂ pretreatment decreased the ability of PMN harvested from the bone marrow of either BALB/cByJ or C57BL/6J mice to kill Listeria monocytogenes in vitro. PGE₂ treatment slowed the migration of PMN toward the chemoattractant leukotriene B4, decreased uptake of L. monocytogenes by PMN, and inhibited the respiratory burst of PMN compared with vehicle-treated cells. When immune cells w

SUBMITTER: Pitts MG 

PROVIDER: S-EPMC6548578 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature