Total plasma heme concentration increases after red blood cell transfusion and predicts mortality in critically ill medical patients.
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ABSTRACT:
SUBMITTER: Pietropaoli AP
PROVIDER: S-EPMC6548617 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Total plasma heme concentration increases after red blood cell transfusion and predicts mortality in critically ill medical patients.
Pietropaoli Anthony P AP Henrichs Kelly F KF Cholette Jill M JM Spinelli Sherry L SL Phipps Richard P RP Refaai Majed A MA Blumberg Neil N
Transfusion 20190227 6
<h4>Background</h4>Relationships between red blood cell (RBC) transfusion, circulating cell-free heme, and clinical outcomes in critically ill transfusion recipients are incompletely understood. The goal of this study was to determine whether total plasma heme increases after RBC transfusion and predicts mortality in critically ill patients.<h4>Study design and methods</h4>This was a prospective cohort study of 111 consecutive medical intensive care patients requiring RBC transfusion. Cell-free ...[more]
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