Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC6548650 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wang Wei W Chapman Nicole M NM Zhang Bo B Li Mingqi M Fan Meiyun M Laribee R Nicholas RN Zaidi M Raza MR Pfeffer Lawrence M LM Chi Hongbo H Wu Zhao-Hui ZH
Cancer research 20190208 11
Solar ultraviolet radiation (UVR) suppresses skin immunity, which facilitates initiation of skin lesions and establishment of tumors by promoting immune evasion. It is unclear whether immune checkpoints are involved in the modulation of skin immunity by UVR. Here, we report that UVR exposure significantly increased expression of immune checkpoint molecule PD-L1 in melanoma cells. The damage-associated molecular patterns molecule HMGB1 was secreted by melanocytes and keratinocytes upon UVR, which ...[more]