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Early Functional Connectivity Predicts Recovery from Visual Field Defects after Stroke.


ABSTRACT:

Background and purpose

We aimed to assess whether early resting-state functional connectivity (RSFC) changes measured via functional magnetic resonance imaging (fMRI) could predict recovery from visual field defect (VFD) in acute stroke patients.

Methods

Patients with VFD due to acute ischemic stroke in the visual cortex and age-matched healthy controls were prospectively enrolled. Serial resting-state (RS)-fMRI and Humphrey visual field (VF) tests were performed within 1 week and at 1 and 3 months (additional VF test at 6 months) after stroke onset in the patient group. The control group also underwent RS-fMRI and a Humphrey VF test. The changes in RSFCs and VF scores (VFSs) over time and their correlations were investigated.

Results

In 32 patients (65±10 years, 25 men), the VFSs were lower and the interhemispheric RSFC in the visual cortices was decreased compared to the control group (n=15, 62±6 years, seven men). The VFSs and interhemispheric RSFC in the visual cortex increased mainly within the first month after stroke onset. The interhemispheric RSFC and VFSs were positively correlated at 1 month after stroke onset. Moreover, the interhemispheric RSFCs in the visual cortex within 1 week were positively correlated with the follow-up VFSs.

Conclusions

Interhemispheric RSFCs in the visual cortices within 1 week after stroke onset may be a useful biomarker to predict long-term VFD recovery.

SUBMITTER: Kim YH 

PROVIDER: S-EPMC6549059 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Early Functional Connectivity Predicts Recovery from Visual Field Defects after Stroke.

Kim Yong-Hwan YH   Cho A-Hyun AH   Kim Dongho D   Kim Seung Min SM   Lim Hyun Taek HT   Kwon Sun U SU   Kim Jong S JS   Kang Dong-Wha DW  

Journal of stroke 20190531 2


<h4>Background and purpose</h4>We aimed to assess whether early resting-state functional connectivity (RSFC) changes measured via functional magnetic resonance imaging (fMRI) could predict recovery from visual field defect (VFD) in acute stroke patients.<h4>Methods</h4>Patients with VFD due to acute ischemic stroke in the visual cortex and age-matched healthy controls were prospectively enrolled. Serial resting-state (RS)-fMRI and Humphrey visual field (VF) tests were performed within 1 week and  ...[more]

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