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Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder.

ABSTRACT: Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.

SUBMITTER: Aaron E

PROVIDER: S-EPMC6549243 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder.

Aaron Elizabeth E Montgomery Alicia A Ren Xinguo X Guter Stephen S Anderson George G Carneiro Ana M D AMD Jacob Suma S Mosconi Matthew M Pandey Ghanshyam N GN Cook Edwin E Veenstra-VanderWeele Jeremy J

Journal of autism and developmental disorders 20190601 6

Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regres ...[more]

PMID: 30927179

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