Ontology highlight
ABSTRACT:
SUBMITTER: Pinho M
PROVIDER: S-EPMC6549468 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Pinho Marta M Macedo Joana C JC Logarinho Elsa E Pereira Paulo S PS
Molecular and cellular biology 20190528 12
The nucleolus is a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis, complex processes that require hundreds of proteins and factors. Alterations in nucleolar morphology and protein content have been linked to the control of cell proliferation and stress responses and, recently, further implicated in cell senescence and ageing. In this study, we report the functional role of NOL12 in the nucleolar homeostasis of human primary fibroblasts. NOL12 repression induces s ...[more]