Ontology highlight
ABSTRACT:
SUBMITTER: Pagan C
PROVIDER: S-EPMC6549559 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Pagan Carlos C Barua Subit S Hsiao Susan J SJ Mansukhani Mahesh M Saqi Anjali A Murty Vundavalli V Fernandes Helen H
Cold Spring Harbor molecular case studies 20190603 3
Assessment of <i>ALK</i> gene rearrangements is strongly recommended by the Molecular Testing Guideline for Selection of Lung Cancer Patients proposed by IASLC, AMP, and CAP at the time of diagnosis for patients with advanced stage disease. Non-small-cell lung cancer (NSCLC) with <i>ALK</i> gene rearrangements or the resulting fusion proteins have been, for the most part, successfully targeted with ALK tyrosine kinase inhibitors (TKIs). The most frequent rearrangement, the EML4-ALK oncogenic fus ...[more]