Ontology highlight
ABSTRACT:
SUBMITTER: Horak P
PROVIDER: S-EPMC6549578 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Horak Peter P Weischenfeldt Joachim J von Amsberg Gunhild G Beyer Burkhard B Schütte Andreas A Uhrig Sebastian S Gieldon Laura L Klink Barbara B Feuerbach Lars L Hübschmann Daniel D Kreutzfeldt Simon S Heining Christoph C Maier Sebastian S Hutter Barbara B Penzel Roland R Schlesner Matthias M Eils Roland R Sauter Guido G Stenzinger Albrecht A Brors Benedikt B Schröck Evelin E Glimm Hanno H Fröhling Stefan S Schlomm Thorsten T
Cold Spring Harbor molecular case studies 20190401 2
Prostate cancers harboring DNA repair gene alterations are particularly sensitive to PARP inhibitor treatment. We report a case of an advanced prostate cancer patient profiled within the NCT-MASTER (Molecularly Aided Stratification for Tumor Eradication Research) precision oncology program using next-generation sequencing. Comprehensive genomic and transcriptomic analysis identified a pathogenic germline <i>PALB2</i> variant as well as a mutational signature associated with disturbed homologous ...[more]