Ontology highlight
ABSTRACT:
SUBMITTER: Dowdle ME
PROVIDER: S-EPMC6550016 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Dowdle Megan E ME Park Sookhee S Blaser Imboden Susanne S Fox Catherine A CA Houston Douglas W DW Sheets Michael D MD Sheets Michael D MD
Development (Cambridge, England) 20190515 10
Bicaudal-C (Bicc1) is a conserved RNA-binding protein that represses the translation of selected mRNAs to control development. In <i>Xenopus</i> embryos, Bicc1 binds and represses specific maternal mRNAs to control anterior-posterior cell fates. However, it is not known how Bicc1 binds its RNA targets or how binding affects Bicc1-dependent embryogenesis. Focusing on the KH domains, we analyzed Bicc1 mutants for their ability to bind RNA substrates <i>in vivo</i> and <i>in vitro</i> Analyses of t ...[more]