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Exposure to Fine Particulate Matter and Ovarian Reserve Among Women from a Fertility Clinic.

ABSTRACT: BACKGROUND:An increasing number of studies have linked air pollution to decreased fertility. Whether this is due to an effect on ovarian reserve is unknown. METHOD:Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004-2015) who had a measured antral follicle count. Validated spatiotemporal models estimated daily particulate matter <2.5 µg/m (PM2.5) (based on residential address) for the 3 months before the antral follicle count. We analyzed associations with Poisson regression. RESULTS:Every 2 µg/m increase in estimated PM2.5 exposure was associated with a -7.2% (95% confidence interval = -10.4%, -3.8%) lower antral follicle count adjusting for age, body mass index, smoking status, and year and season of the count. The association of PM2.5 with antral follicle count was stronger among women with female factor infertility (-16.3% per 2 µg/m). CONCLUSIONS:Among women from an infertility clinic, higher PM2.5 exposure was associated with lower ovarian reserve, raising concern that air pollution may accelerate reproductive aging.

SUBMITTER: Gaskins AJ

PROVIDER: S-EPMC6550330 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Exposure to Fine Particulate Matter and Ovarian Reserve Among Women from a Fertility Clinic.

Gaskins Audrey J AJ Mínguez-Alarcón Lidia L Fong Kelvin C KC Abdelmessih Sarah S Coull Brent A BA Chavarro Jorge E JE Schwartz Joel J Kloog Itai I Souter Irene I Hauser Russ R Laden Francine F

Epidemiology (Cambridge, Mass.) 20190701 4

<h4>Background</h4>An increasing number of studies have linked air pollution to decreased fertility. Whether this is due to an effect on ovarian reserve is unknown.<h4>Method</h4>Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004-2015) who had a measured antral follicle count. Validated spatiotemporal models estimated daily particulate matter <2.5 µg/m (PM2.5) (based on residential address) for the 3 months before the antral follicle count. We analyz ...[more]

PMID: 31162281

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Project description:BACKGROUND:Emerging data suggests PM2.5 (particulate matter with aerodynamic diameter <2.5??m) may be associated with both earlier declines in episodic memory (EM) and increased depressive symptoms in older adults. Although late-life depressive symptoms are associated with EM, no longitudinal studies have examined the inter-relationship among PM2.5, depressive symptoms and EM. METHODS:Older women (n?=?2,202; aged 67-83 in 1999) enrolled in the Women's Health Initiative Study of Cognitive Aging completed up to eight annual assessments of depressive symptoms (15-item Geriatric Depression Scale) and EM (California Verbal Learning Test). A nationwide spatiotemporal model (1999-2010) was used to estimate ambient PM2.5 exposure at residential locations. Univariate and bivariate structural equation models (SEMs) for latent-change scores were used to examine how 3-year average PM2.5 preceding each assessment affects the temporal dynamics and bidirectional relations of annual changes in depressive symptoms and EM. RESULTS:In univariate SEMs, one inter-quartile (4.04??g/m3) increment of 3-year PM2.5 was significantly (p?<?0.05) associated with accelerated declines in verbal learning (List A trials 1-3: ??=?-1.48) and free-recall memory (short-delay: ??=?-1.43; long-delay: ??=?-1.11), but not with change in depressive symptoms (??=?0.12; p?=?0.71). In bivariate SEMs, significant associations were observed between PM2.5 and accelerated declines in EM measures (??=?-1.44 to -0.99; p?<?0.05) and between EM performance and changes in depressive symptoms (??=?-0.08 to -0.05; p?<?0.05), with significant indirect PM2.5 effects on changes in depressive symptoms (??=?0.08-0.10; p?<?0.05). These findings were robust with adjustment for multiple demographic, lifestyle, and clinical factors, and remained after excluding subjects with dementia or mild cognitive impairment. No associations were found between PM2.5 and change in depressive symptoms or depressive symptoms and subsequent EM decline. CONCLUSIONS:Findings suggest that PM2.5 neurotoxicity may damage brain areas implicated in EM, followed by manifestation of depressive symptoms. Our data did not support depressive symptoms as the neuropsychological mediator of accelerated brain aging associated with PM2.5 exposure.

Dataset Information

Exposure to Fine Particulate Matter and Ovarian Reserve Among Women from a Fertility Clinic.

Publications

Exposure to Fine Particulate Matter and Ovarian Reserve Among Women from a Fertility Clinic.

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