Ontology highlight
ABSTRACT:
SUBMITTER: Dorn A
PROVIDER: S-EPMC6550410 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Dorn Annika A Feller Laura L Castri Dominique D Röhrig Sarah S Enderle Janina J Herrmann Natalie J NJ Block-Schmidt Astrid A Trapp Oliver O Köhler Laura L Puchta Holger H
PLoS genetics 20190523 5
Proteins of the Fanconi Anemia (FA) complementation group are required for crosslink (CL) repair in humans and their loss leads to severe pathological phenotypes. Here we characterize a homolog of the Fe-S cluster helicase FANCJ in the model plant Arabidopsis, AtFANCJB, and show that it is involved in interstrand CL repair. It acts at a presumably early step in concert with the nuclease FAN1 but independently of the nuclease AtMUS81, and is epistatic to both error-prone and error-free post-repli ...[more]