Effect of age at puberty on risk of multiple sclerosis: A mendelian randomization study.

ABSTRACT:

Objective

To investigate the potential for a causal effect of age at puberty on multiple sclerosis (MS) susceptibility using a mendelian randomization (MR) approach.

Methods

We used 372 genetic variants strongly associated with age at menarche in a genome-wide association study (GWAS) involving 329,245 women. The genetic architecture of pubertal timing across both sexes is highly correlated (genetic correlation [r _g] = 0.75, p = 1.2 × 10^-79), allowing these variants to provide reliable insight into pubertal timing in males as well. The effect of pubertal timing on risk of MS was measured with summary statistics from a GWAS of 14,802 cases with MS and 26,703 controls from the International Multiple Sclerosis Genetics Consortium. Multivariab

SUBMITTER: Harroud A 

PROVIDER: S-EPMC6550505 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature