Ontology highlight
ABSTRACT:
SUBMITTER: Hirano Y
PROVIDER: S-EPMC6550875 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Hirano Yoshinori Y Gao Yong-Guang YG Stephenson Daniel J DJ Vu Ngoc T NT Malinina Lucy L Simanshu Dhirendra K DK Chalfant Charles E CE Patel Dinshaw J DJ Brown Rhoderick E RE
eLife 20190503
Ca<sup>2+</sup>-stimulated translocation of cytosolic phospholipase A<sub>2</sub>α (cPLA<sub>2</sub>α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA<sub>2</sub>α preference for phosphatidylcholine (PC)-enriched membranes have remained elusive. Here, we report the structure of the cPLA<sub>2</sub>α C2-domain (at 2.2 Å resolution), which contains bound 1,2-dihexanoyl-<i>sn</i>-glycero-3-phosphoch ...[more]