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Limits to anatomical accuracy of diffusion tractography using modern approaches.


ABSTRACT: Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the brain, with a range of applications in both clinical and basic neuroscience. Despite widespread use, tractography has well-known pitfalls that limits the anatomical accuracy of this technique. Numerous modern methods have been developed to address these shortcomings through advances in acquisition, modeling, and computation. To test whether these advances improve tractography accuracy, we organized the 3-D Validation of Tractography with Experimental MRI (3D-VoTEM) challenge at the ISBI 2018 conference. We made available three unique independent tractography validation datasets - a physical phantom and two ex vivo brain specimens - resulting in 176 distinct submissions from 9 research groups. By comparing results over a wide range of fiber complexities and algorithmic strategies, this challenge provides a more comprehensive assessment of tractography's inherent limitations than has been reported previously. The central results were consistent across all sub-challenges in that, despite advances in tractography methods, the anatomical accuracy of tractography has not dramatically improved in recent years. Taken together, our results independently confirm findings from decades of tractography validation studies, demonstrate inherent limitations in reconstructing white matter pathways using diffusion MRI data alone, and highlight the need for alternative or combinatorial strategies to accurately map the fiber pathways of the brain.

SUBMITTER: Schilling KG 

PROVIDER: S-EPMC6551229 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Limits to anatomical accuracy of diffusion tractography using modern approaches.

Schilling Kurt G KG   Nath Vishwesh V   Hansen Colin C   Parvathaneni Prasanna P   Blaber Justin J   Gao Yurui Y   Neher Peter P   Aydogan Dogu Baran DB   Shi Yonggang Y   Ocampo-Pineda Mario M   Schiavi Simona S   Daducci Alessandro A   Girard Gabriel G   Barakovic Muhamed M   Rafael-Patino Jonathan J   Romascano David D   Rensonnet Gaëtan G   Pizzolato Marco M   Bates Alice A   Fischi Elda E   Thiran Jean-Philippe JP   Canales-Rodríguez Erick J EJ   Huang Chao C   Zhu Hongtu H   Zhong Liming L   Cabeen Ryan R   Toga Arthur W AW   Rheault Francois F   Theaud Guillaume G   Houde Jean-Christophe JC   Sidhu Jasmeen J   Chamberland Maxime M   Westin Carl-Fredrik CF   Dyrby Tim B TB   Verma Ragini R   Rathi Yogesh Y   Irfanoglu M Okan MO   Thomas Cibu C   Pierpaoli Carlo C   Descoteaux Maxime M   Anderson Adam W AW   Landman Bennett A BA  

NeuroImage 20181011


Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the brain, with a range of applications in both clinical and basic neuroscience. Despite widespread use, tractography has well-known pitfalls that limits the anatomical accuracy of this technique. Numerous modern methods have been developed to address these shortcomings through advances in acquisition, modeling, and computation. To test whether these advances improve tractography accuracy, we organized the 3-  ...[more]

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