Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women.

ABSTRACT:

Purpose

We examined the association of plasma B-vitamins and metabolites, and related genetic variants, with risk of breast cancer among predominantly premenopausal women.

Methods

We conducted a nested case-control study within the Nurses' Health Study II. From blood samples collected in 1996-1999 and follow-up through 2007, plasma measures were available for 610 cases and 1207 controls. Unconditional multivariable logistic regression was used to estimate relative risks (RR) of breast cancer and 95% confidence intervals (CIs). We examined whether associations varied by methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase polymorphisms, breast cancer risk factors, or tumor characteristics.

Results

Plasma vitamin B₁₂ was associated with a 6

SUBMITTER: Houghton SC 

PROVIDER: S-EPMC6551273 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature